作者: Michiyuki Yamada , Toshiyuki Shimizu , Mamoru Sato , Yuji Hidaka , Hiroshi Hashimoto
DOI:
关键词: Stereochemistry 、 Chemistry 、 Chemical formula 、 Articular rheumatism 、 Peptidyl arginine deiminase 、 Alkyl
摘要: A compound represented by the following general formula (I) or a salt thereof. [Chemical 1] (In formula, R1, R2, and R3 each independently represents hydrogen C1-3 alkyl, provided that at least one of is not hydrogen; R4 substituted amino; R5 optionally carboxy.) Also peptidyl arginine deiminase type IV inhibitor. With this inhibitor, diseases in which participates (e.g., articular rheumatism multiple sclerosis) can be prevented and/or treated.