Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.

摘要: Abstract The liver plays a key role in the regulation of circulating levels low density lipoproteins (LDL) because it is both site for production and major organ degradation this class lipoproteins. In study, effects feeding polyunsaturated or saturated triacylglycerols on receptor-dependent receptor-independent hepatic LDL uptake were measured vivo hamster. control animals, transport manifested an apparent Km value 85 mg/dl (plasma LDL-cholesterol concentration) reached maximum velocity 131 micrograms LDL-cholesterol/hr per g, whereas increased as linear function plasma levels. Thus, at normal concentrations, clearance rate equaled 120 9 microliter/hr g by mechanisms, respectively. As was increased, (but not receptor-independent) component declined. When cholesterol (0.12%) alone combination with fed 30 days, reduced to 36-42 plus essentially abolished (5 g). compared appropriate kinetic curves, these findings indicated that receptor-mediated suppressed approximately equal 30% unaffected addition diet. contrast, 90% intake triacylglycerols. triacylglycerols, lipids also associated significantly higher concentrations lower cholesteryl esters liver.