Methods and compositions relating to the androgen receptor gene and uses thereof

摘要: Disclosed are methods and compositions, including antisense antigene constructs pharmaceutical formulations thereof, for use in regulating androgen receptor gene expression. The promoter activity of the is herein shown to include a critical upstream acting domain with unique sequence, nucleic acid sequence corresponding positions 1697 2084, particularly between 1717, as defined SEQ ID NO:1. AR characterized having particular nucleotide nucleotides 2084 NO:1, important regulation Oligonucleotides triple helix forming oligonucleotides (TFO) that bind this region have sequences provide specific potent inhibition function cellulo. Rat human nuclear proteins, more specifically described novel trans-activating proteins gene, also identified. These may be used prepare antibodies protein, well regulate expression gene. oligonucleotide compositions invention molecular probes inhibit treatment pathologies by overexpression prostatic hypertrophy androgenetic alopecia.