Regulation of Cell Death by Transfer RNA

作者: Ya-Ming Hou , Xiaolu Yang

DOI: 10.1089/ARS.2012.5171

关键词: Cytochrome cCell biologyGeneBiologyBiochemistryRNAGene expressionMitochondrionMessenger RNAApoptosisTransfer RNA

摘要: Abstract Significance: Both transfer RNA (tRNA) and cytochrome c are essential molecules for the survival of cells. tRNA decodes mRNA codons into amino-acid-building blocks in protein all organisms, whereas functions electron transport chain that powers ATP synthesis mitochondrion-containing eukaryotes. Additionally, vertebrates, is released from mitochondria a potent inducer apoptosis, activating apoptotic proteins (caspases) cytoplasm to dismantle A better understanding both an insight regulation cell life death. Recent Advances: recent study showed mitochondrion-released can be removed cell-death pathway by molecules. The direct binding provides mechanism regulate death, beyond its role gene expression. Critical Issues: nature tRNA–cytochrome interaction remains unknown. q...

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