Association of TagSNP in lncRNA HOTAIR with susceptibility to noise-induced hearing loss in a Chinese population.

摘要: Abstract Background Noise-induced hearing loss (NIHL) is a multifactorial disease, and dysregulation of oxidative stress universally acknowledged as one crucial pathogenic factor for this disease. Recently studies have found the LncRNA HOTAIR involved in alteration level, cell proliferation, cycle progression, apoptosis. Considering effects lncRNA cellular stress, we sought to investigate influence variants on risk NIHL. Methods To explore polymorphisms individual susceptibility NIHL, We performed genotyping three tagSNPs (rs874945, rs4759314 rs7958904) gene Chinese population which consists 570 NIHL cases controls. The luciferase assays were further regulatory function tagSNPs. Results Our results revealed individuals with G allele tagSNP haplotype are associated an increased population. Meanwhile, rs4759314 G could significantly increase expression HOTAIR. Conclusions genetic polymorphism within may play role occurrence development