Anti-EGFR therapy combined with neuromedin B receptor blockade induces the death of DAOY medulloblastoma cells.
作者： Mariane Jaeger , Carolina Nör , Caroline Brunetto de Farias , Ana Lucia Abujamra , Gilberto Schwartsmann
DOI: 10.1007/S00381-013-2290-6
关键词: Medicine 、 Cancer research 、 Cetuximab 、 Brain tumor 、 Internal medicine 、 Epidermal growth factor receptor 、 Growth factor receptor 、 Neuromedin B receptor 、 Medulloblastoma 、 Endocrinology 、 Programmed cell death 、 Growth factor receptor inhibitor
摘要: Purpose Medulloblastoma is the most common malignant childhood brain tumor for which development of new molecularly targeted therapies needed. Novel therapeutic targets under investigation include growth factor receptors. Here, we show that combined inhibition epidermal receptor (EGFR) and neuromedin B (NMBR, BB1) results in increased cell death human medulloblastoma lines.
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