Use of a high sensitive nanofluidic array for the detection of rare copies of BCR-ABL1 transcript in patients with Philadelphia-positive acute lymphoblastic leukemia in complete response.

作者: Ilaria Iacobucci , Annalisa Lonetti , Claudia Venturi , Anna Ferrari , Cristina Papayannidis

DOI: 10.1016/J.LEUKRES.2014.02.005

关键词: Internal medicineLeukemiaBioinformaticsReverse transcription polymerase chain reactionDigital polymerase chain reactionLymphoblastic LeukemiaTaqManABLBiologyOncologyPolymerase chain reactionMinimal residual disease

摘要: … In this study, we assessed the dPCR methodology to detect and quantify residual and rare BCR-ABL1 copies in BCR-ABL1-positive ALL patients, and we compared obtained molecular …

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