Endotoxin decreases corticotropin-releasing factor receptor 1 messenger ribonucleic acid levels in the rat pituitary.
作者： Jean-Michel Aubry , Andrew V. Turnbull , Giacomo Pozzoli , Catherine Rivier , Wylie Vale
关键词: Corticotropin-Releasing Factor Receptor 1 、 Messenger RNA 、 Biology 、 Vasopressin 、 Endocrinology 、 Lipopolysaccharide 、 Internal medicine 、 Corticosterone 、 Stimulation 、 Cell culture 、 Corticotropic cell
摘要: Bacterial endotoxins produce profound activation of the hypothalamo-pituitary-adrenal axis, mediated by stimulation hypothalamic CRF neurons. Although a number studies have described direct pituitary actions inflammatory mediators, effects stimuli on sensitivity corticotropes to remain be elucidated. The aim this study was determine stress receptor 1 (CRF-R1) messenger RNA (mRNA) levels in rat pituitary. systemic injection endotoxin [lipopolysaccharide (LPS); 50μ g/kg, iv] increased plasma concentrations ACTH and corticosterone. Ribonuclease protection analysis total isolated from individual whole pituitaries indicated that LPS produced significant decrease CRF-R1 mRNA evident 2 h after (to 57% control) more marked 6 38% control). To evaluate whether dependent upon exposure and/or vasopressin (AVP), w...
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