Cetuximab-Containing Combinations in Locally Advanced and Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma.
作者： Miren Taberna , Marc Oliva , Ricard Mesía
关键词: Cetuximab 、 Internal medicine 、 Regimen 、 Head and neck cancer 、 Targeted therapy 、 Radiation therapy 、 Pembrolizumab 、 Medicine 、 Chemoradiotherapy 、 Oncology 、 Head and neck squamous-cell carcinoma
摘要: Cetuximab remains to date the only targeted therapy approved for the treatment of head and neck squamous cell carcinoma (HNSCC). The EGFR pathway plays a key role in the tumorigenesis and progression of this disease as well as in the resistance to radiotherapy (RT). While several anti-EGFR agents have been tested in HNSCC, cetuximab, an IgG1 subclass monoclonal antibody against EGFR, is the only drug with proven efficacy for the treatment of both locoregionally-advanced (LA) and recurrent/metastatic (R/M) disease. The …
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