Using a Kinase/Phosphatase Switch to Regulate a Supramolecular Hydrogel and Forming the Supramolecular Hydrogel in Vivo

作者: Zhimou Yang , Gaolin Liang , Ling Wang , Bing Xu

DOI: 10.1021/JA057412Y

关键词: Supramolecular chemistryBiophysicsKinaseNanofiberSelf-healing hydrogelsTyrosineIn vivoStereochemistryPhosphataseChemistryDephosphorylation

摘要: We have designed and synthesized a new hydrogelator Nap−FFGEY (1), which forms a supramolecular hydrogel. A kinase/phosphatase switch is used to control the phosphorylation …

参考文章(13)
Thierry Tonon, David Harvey, Renwei Qing, Yi Li, Tony R Larson, Ian A Graham, Identification of a fatty acid Δ11-desaturase from the microalga Thalassiosira pseudonana1 FEBS Letters. ,vol. 563, pp. 28- 34 ,(2004) , 10.1016/S0014-5793(04)00241-8
Jeroen den Hertog, Regulation of protein phosphatases in disease and behaviour. EMBO Reports. ,vol. 4, pp. 1027- 1031 ,(2003) , 10.1038/SJ.EMBOR.7400009
Jorge Moscat, María T Diaz‐Meco, Paul Rennert, NF‐κB activation by protein kinase C isoforms and B‐cell function EMBO Reports. ,vol. 4, pp. 31- 36 ,(2003) , 10.1038/SJ.EMBOR.EMBOR704
J. C. Hutton, G. S. Eisenbarth, A pancreatic β-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 8626- 8628 ,(2003) , 10.1073/PNAS.1633447100
Pierre Terech, Richard G. Weiss, Low Molecular Mass Gelators of Organic Liquids and the Properties of Their Gels Chemical Reviews. ,vol. 97, pp. 3133- 3160 ,(1997) , 10.1021/CR9700282
Hidefumi Makabe, Looi Kok Kong, Mitsuru Hirota, Total Synthesis of (−)-Cassine Organic Letters. ,vol. 5, pp. 27- 29 ,(2003) , 10.1021/OL0201916
N. Sreenivasachary, J.-M. Lehn, Gelation-driven component selection in the generation of constitutional dynamic hydrogels based on guanine-quartet formation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 5938- 5943 ,(2005) , 10.1073/PNAS.0501663102
Heather A. Behanna, Jack J. J. M. Donners, Alex C. Gordon, Samuel I. Stupp, Coassembly of Amphiphiles with Opposite Peptide Polarities into Nanofibers Journal of the American Chemical Society. ,vol. 127, pp. 1193- 1200 ,(2005) , 10.1021/JA044863U
Sylvain Latour, André Veillette, Proximal protein tyrosine kinases in immunoreceptor signaling. Current Opinion in Immunology. ,vol. 13, pp. 299- 306 ,(2001) , 10.1016/S0952-7915(00)00219-3
Michel Julien, Shama Kajiji, Ronald H. Kaback, Philippe Gros, Simple purification of highly active biotinylated P-glycoprotein: enantiomer-specific modulation of drug-stimulated ATPase activity. Biochemistry. ,vol. 39, pp. 75- 85 ,(2000) , 10.1021/BI991726E