Eastern equine encephalitis virus. Quantitative study of the effects of interferon on virus replication.
作者： A. S. Lubiniecki , J. A. Armstrong , Monto Ho
DOI: 10.1007/BF01240541
关键词: Eukaryotic Small Ribosomal Subunit 、 Viral Plaque Assay 、 Viral replication 、 Biology 、 Uridine 、 Eastern equine encephalitis virus 、 Interferon 、 Virology 、 Encephalitis Viruses 、 Molecular biology 、 Protein biosynthesis
摘要: Eastern equine encephalitis (EEE) virus replication in rabbit kidney (RK) cells was inhibited by interferon (IF). Interferon protected against the virus-induced shutoff of host protein synthesis and partially suppressed EEE structural proteins infected cells. High doses (300–3000 units) labeling viral RNA interferon-treated RK as much 98 per cent, measured TCA precipitation following 10, 30 or 60 minute period. Sucrose gradient analysis confirmed that incorporation of3H-uridine into 23S 40S interferon, latter being slightly more sensitive. The logarithm surviving fraction each virus-specific event persisting cell a linear function IP dose over 1000-fold concentration range. relative sensitivities events were from highest to lowest: yield > EEE-induced CPE = synthesis.
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sci-hub.se 参考文章(34)
Robert M. Friedman, Basis for Variable Response of Arboviruses to Guanidine Treatment Journal of Virology. ,vol. 6, pp. 628- 636 ,(1970) , 10.1128/JVI.6.5.628-636.1970
G.E. Gifford, S.T. Toy, J. Lindenmann, Studies on vaccinia virus plaque formation and its inhibition by interferon. II. Dynamics of plaque formation by vaccinia virus in the presence of interferon. Virology. ,vol. 19, pp. 294- 301 ,(1963) , 10.1016/0042-6822(63)90067-9
Daniel T. Summons, James H. Steaitss, Replication of Sindbis virus Journal of Molecular Biology. ,vol. 71, pp. 615- 631 ,(1972) , 10.1016/S0022-2836(72)80027-5
Robert R. Wagner, Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus. Virology. ,vol. 13, pp. 323- 337 ,(1961) , 10.1016/0042-6822(61)90152-0
Robert M. Friedman, Inhibition of Arbovirus Protein Synthesis by Interferon Journal of Virology. ,vol. 2, pp. 1081- 1085 ,(1968) , 10.1128/JVI.2.10.1081-1085.1968
Robert M. Friedman, Structural and Nonstructural Proteins of an Arbovirus Journal of Virology. ,vol. 2, pp. 1076- 1080 ,(1968) , 10.1128/JVI.2.10.1076-1080.1968
Yang H. Ke, Monto Ho, Characterization of Virus- and Endotoxin-induced Interferons Obtained from the Serum and Urine of Rabbits Journal of Virology. ,vol. 1, pp. 883- 890 ,(1967) , 10.1128/JVI.1.5.883-890.1967
Robert G. Martin, Bruce N. Ames, A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures Journal of Biological Chemistry. ,vol. 236, pp. 1372- 1379 ,(1961) , 10.1016/S0021-9258(18)64180-8
Shudo Yamazaki, Robert R. Wagner, Action of Interferon: Kinetics and Differential Effects on Viral Functions Journal of Virology. ,vol. 6, pp. 421- 429 ,(1970) , 10.1128/JVI.6.4.421-429.1970
Mary Kay Breinig, Monto Ho, Conditions for the Production of an Interferon appearing in Chick Cell Cultures infected with Sindbis Virus. Journal of Immunology. ,vol. 89, pp. 177- 186 ,(1962)