Advances in the Etiology and Management of Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass
作者： Yunfeng Cui , Dariush Elahi , Dana K. Andersen
DOI: 10.1007/S11605-011-1585-8
关键词: Hypoglycemia 、 Incretin 、 Endocrinology 、 Octreotide 、 Diabetes mellitus 、 Type 2 Diabetes Mellitus 、 Neuroglycopenia 、 Hyperinsulinemic hypoglycemia 、 Medicine 、 Internal medicine 、 Nesidioblastosis
摘要: Hyperinsulinemic hypoglycemia with severe neuroglycopenia has been identified as a late complication of Roux-en-Y gastric bypass (RYGB) in small number patients. The rapid resolution type 2 diabetes mellitus after RYGB is probably related to increased secretion the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), patients post-RYGB demonstrate prolonged elevations GIP GLP-1 compared non-hypoglycemic Nesidioblastosis some likely due trophic effects on pancreatic islets. Treatment should begin strict dietary (low carbohydrate) alteration may require trial diazoxide, octreotide, or calcium-channel antagonists, among other drugs. Surgical therapy include consideration restrictive form bariatric procedure, without reconstitution gastrointestinal continuity. Partial total resection be avoided.
springer.com
elsevier.com
sci-hub.se 参考文章(110)
Friedman Mn, Magovern Gj, Sancetta Aj, The amelioration of diabetes mellitus following subtotal gastrectomy. Surgery gynecology & obstetrics. ,vol. 100, pp. 201- ,(1955)
Edward E. Mason, Chikashi Ito, Gastric Bypass in Obesity Surgical Clinics of North America. ,vol. 47, pp. 1345- 1351 ,(1967) , 10.1016/S0039-6109(16)38384-0
Albert Aynsley-Green, Charles A Stanley, Khalid Hussain, Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI). Pediatric endocrinology reviews. pp. 163- 167 ,(2004)
DANIEL J. SAFER, Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective. Southern Medical Journal. ,vol. 84, pp. 1470- 1474 ,(1991) , 10.1097/00007611-199112000-00015
Longitudinal Assessment of Bariatric Surgery (LABS) Consortium, None, Perioperative safety in the longitudinal assessment of bariatric surgery. The New England Journal of Medicine. ,vol. 361, pp. 445- 454 ,(2009) , 10.1056/NEJMOA0901836
J.F. Habener, D.A. Stoffers, D. Elahi, E.H. Hani, P. Froguel, Role of Homeodomain Transcription Factor IPF-1 in the Pathogenesis of Diabetes mellitus Karger Publishers. ,vol. 15, pp. 197- 208 ,(2000) , 10.1159/000060924
W. E. Schmidt, E. G. Siegel, W. Creutzfeldt, Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia. ,vol. 28, pp. 704- 707 ,(1985) , 10.1007/BF00291980
Mark S Duxbury, Talat Waseem, Hiromichi Ito, Malcolm K Robinson, Michael J Zinner, Stanley W Ashley, Edward E Whang, Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochemical and Biophysical Research Communications. ,vol. 309, pp. 464- 468 ,(2003) , 10.1016/J.BBRC.2003.08.024
John C. Brown, Jill R. Dryburgh, A gastric inhibitory polypeptide. II. The complete amino acid sequence. Biochemistry and Cell Biology. ,vol. 49, pp. 867- 872 ,(1971) , 10.1139/O71-122
Frank Benedix, Sabine Westphal, Robert Patschke, Dennis Granowski, Claus Luley, Hans Lippert, Stephanie Wolff, Weight Loss and Changes in Salivary Ghrelin and Adiponectin: Comparison Between Sleeve Gastrectomy and Roux-en-Y Gastric Bypass and Gastric Banding Obesity Surgery. ,vol. 21, pp. 616- 624 ,(2011) , 10.1007/S11695-011-0374-5