Investigation of the inverse piezoelectric effect of trabecular bone on a micrometer length scale using synchrotron radiation

摘要: Abstract In the present paper we have investigated impact of electro stimulation on microstructural parameters major constituents bone, hydroxyapatite and collagen. Therapeutic approaches exhibit an improved healing rate under electric fields. However, underlying mechanism is not fully understood so far. this context one possible effect which could be responsible inverse piezo at bone structures. Therefore, carried out scanning X-ray microdiffraction experiments, i.e. recorded diffraction data with micrometer resolution using synchrotron radiation from trabecular samples in order to investigate how matrix reacts applied field. Different were investigated, where orientation collagen differed respect Our experiments aimed determine whether a significant regeneration owing electrostimulative therapy. suggest that strain fact induced by via occurs presence adequately oriented The magnitude range cells are able detect it. Statement Significance our study report piezoelectric was already discovered explored macro scale 1950. Clinical utilize successfully enhance but exact mechanisms taking place still matter debate. We measured stress distribution micron stress. results show big enough sensed therefore, trigger for remodeling growth.