Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa.
作者： Jun Matsukawa , Akifumi Kogame , Yoshihiko Tagawa , Nobuhiro Inatomi
DOI: 10.1007/S10620-016-4100-Y
关键词: Gastric mucosa 、 Medicine 、 Internal medicine 、 Gastroenterology 、 Potassium 、 Transplant surgery 、 Hepatology 、 Vonoprazan 、 Gastric glands 、 Lansoprazole 、 Gastric Parietal Cells
摘要: Background Vonoprazan fumarate (TAK-438) is a novel potassium-competitive acid blocker that appears to exert longer/more potent antisecretory effect than lansoprazole due high accumulation/slow clearance from the gastric glands. However, there no direct evidence vonoprazan selectively accumulates in parietal cells of
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