Mammaglobin 1: not only a breast-specific and tumour-specific marker, but also a hormone-responsive endometrial protein.

摘要: Classen-Linke I, Moss S, Groting K, Beier H M, Alfer J & Krusche C A (2012) Histopathology 61, 955–965 Mammaglobin 1: not only a breast-specific and tumour-specific marker, but also hormone-responsive endometrial protein Aims:  The secretoglobin mammaglobin 1 (MGB1) is strongly expressed in breast tumours, therefore used to detect cancer metastases, although it has been detected other tissues. aim of this study was examine MGB1 expression its hormonal regulation human endometrium further investigate the use as marker molecule. Methods results:  Mammaglobin assessed immunohistochemically samples from 60 normal fertile patients throughout menstrual cycle, 49 endometriotic tissue samples, 15 adenocarcinomas, 36 carcinomas. In addition, 25 were analysed by western blot quantitative real-time reverse transcription polymerase chain reaction. To prove regulation, primary epithelial cells cultured with 17β-oestradiol promegestone. tissue, peak during luteal phase, 31% 53% 64% mRNA increased vitro treatment. Conclusions:  Our data show that restricted malignant tissue. Besides documented occurrence tissues, endometrium, such controlled steroid hormones.