Genetics of metabolic syndrome and related traits
作者： Peter Henneman
DOI:
关键词: Heritability 、 Single-nucleotide polymorphism 、 Adipokine 、 Genetic correlation 、 Candidate gene 、 Genetics 、 Metabolic syndrome 、 Biology 、 Genetics of obesity 、 Adiponectin
摘要: In this thesis several aspects of metabolic syndrome are addressed. The focus involves questions concerning the genetics obesity, TG and cholesterol hyperglycemia. Since we hypothesized that obesity is most important trigger impairment, MetS definition in was chosen to include measure waist circumference as an essential component. In study described chapter 2, heritability addressed compared its individual components. components were shown be more heritable than itself, studies 3 4 focused on component plasma TG. For purpose, a candidate gene approach employed using HTG patients healthy controls. involvement series genes confirmed. 5 followed similar used 4. Several studied suffering from hyperlipoproteinemia (HLP) type III, which characterized by elevated levels total HLP III APOE2 homozygosity. Contributing genetic factors (metabolically stressed) APOE2/2 environment confirmed. Plasma adiponectin, adipose tissue secreted hormone (adipokine), has been suggested biomarker for MetS. 6 describe particularly aimed determine effect menopause discriminating accuracy adiponectin predict Especially low postmenopausal women found risk However, presence exceeded BMI men pre –and post menopausal women. very well correlated with or related traits, 7 question whether these correlations caused overlap (genetic correlation). correlation mono-laterally validated regard (ADIPOQ). Chapter 8 describes towards finding novel loci associated possibly involved between traits. This genome-wide association (GWA) approach. results GWA joined analysis two other cohorts meta-analysis. addition, selected proportion SNPs submitted replication cohorts. 9 provides general discussion reviewing all previous chapters thesis. Furthermore, includes suggestions proposals future analyses unraveling environmental expression manifestation factors.
researchgate.net 参考文章(266)
T. Yamauchi, J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M.L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, T. Kadowaki, The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine. ,vol. 7, pp. 941- 946 ,(2001) , 10.1038/90984
P. Henneman, F. G. Schaap, P. C. N. Rensen, K. W. van Dijk, A. H. M. Smelt, Estrogen induced hypertriglyceridemia in an apolipoprotein AV deficient patient. Journal of Internal Medicine. ,vol. 263, pp. 107- 108 ,(2007) , 10.1111/J.1365-2796.2007.01889.X
Lude Franke, Ritsert C. Jansen, eQTL analysis in humans. Methods of Molecular Biology. ,vol. 573, pp. 311- 328 ,(2009) , 10.1007/978-1-60761-247-6_17
N. Bradshaw, C. Brewer, G. Brice, B. Bullman, J. Campbell, B. Castle, R. Cetnarsryj, C. Chapman, C. Chu, N. Coates, T. Cole, R. Davidson, A. Donaldson, H. Dorkins, F. Douglas, D. Eccles, R. Eeles, F. Elmslie, D. G. Evans, S. Goff, S. Goodman, D. Goudie, J. Gray, L. Greenhalgh, H. Gregory, S. V. Hodgson, T. Homfray, R. S. Houlston, L. Izatt, L. Jackson, L. Jeffers, V. Johnson-Roffey, F. Kavalier, C. Kirk, F. Lalloo, C. Langman, I. Locke, M. Longmuir, J. Mackay, A. Magee, S. Mansour, Z. Miedzybrodzka, J. Miller, P. Morrison, V. Murday, J. Paterson, G. Pichert, M. Porteous, N. Rahman, M. Rogers, S. Rowe, S. Shanley, A. Saggar, G. Scott, L. Side, L. Snadden, M. Steel, M. Thomas, S. Thomas, M. I. McCarthy, A. T. Hattersley, , E. Zeggini, M. N. Weedon, C. M. Lindgren, T. M. Frayling, K. S. Elliott, H. Lango, N. J. Timpson, J. R. B. Perry, N. W. Rayner, R. M. Freathy, J. C. Barrett, B. Shields, A. P. Morris, S. Ellard, C. J. Groves, L. W. Harries, J. L. Marchini, K. R. Owen, B. Knight, L. R. Cardon, M. Walker, G. A. Hitman, A. D. Morris, A. S. F. Doney, P. R. Burton, D. G. Clayton, N. Craddock, P. Deloukas, A. Duncanson, D. P. Kwiatkowski, W. H. Ouwehand, N. J. Samani, J. A. Todd, P. Donnelly, D. Davison, D. Easton, D. Evans, H.-T. Leung, C. C. A. Spencer, M. D. Tobin, A. P. Attwood, J. P. Boorman, B. Cant, U. Everson, J. M. Hussey, J. D. Jolley, A. S. Knight, K. Koch, E. Meech, S. Nutland, C. V. Prowse, H. E. Stevens, N. C. Taylor, G. R. Walters, N. M. Walker, N. A. Watkins, T. Winzer, R. W. Jones, W. L. McArdle, S. M. Ring, D. P. Strachan, M. Pembrey, G. Breen, D. St. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. K. Green, D. Grozeva, M. L. Hamshere, P. A. Holmans, I. R. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. C. O'Donovan, M. J. Owen, D. A. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. H. Young, I. N. Ferrier, S. G. Ball, A. J. Balmforth, J. H. Barrett, D. T. Bishop, M. M. Iles, A. Maqbool, N. Yuldasheva, A. S. Hall, P. S. Braund, R. J. Dixon, M. Mangino, S. Stevens, J. R. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. W. Lees, E. R. Nimmo, J. Satsangi, S. A. Fisher, A. Forbes, C. M. Lewis, C. M. Onnie, N. J. Prescott, J. Sanderson, C. G. Mathew, J. Barbour, M. K. Mohiuddin, C. E. Todhunter, J. C. Mansfield, T. Ahmad, F. R. Cummings, D. P. Jewell, J. Webster, M. J. Brown, G. M. Lathrop, J. Connell, A. Dominiczak, C. A. Braga Marcano, B. Burke, R. Dobson, J. Gungadoo, K. L. Lee, P. B. Munroe, S. J. Newhouse, A. Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. N. Bruce, H. Donovan, S. Eyre, P. D. Gilbert, S. L. Hider, A. M. Hinks, S. L. John, C. Potter, A. J. Silman, D. P. M. Symmons, W. Thomson, J. Worthington, D. B. Dunger, B. Widmer, M. Newport, G. Sirugo, E. Lyons, F. Vannberg, A. V. S. Hill, L. A. Bradbury, C. Farrar, J. J. Pointon, P. Wordsworth, M. A. Brown, J. A. Franklyn, J. M. Heward, M. J. Simmonds, S. C. L. Gough, S. Seal, M. R. Stratton, N. Rahman, M. Ban, A. Goris, S. J. Sawcer, A. Compston, D. Conway, M. Jallow, K. A. Rockett, S. J. Bumpstead, A. Chaney, K. Downes, M. J. R. Ghori, R. Gwilliam, S. E. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, S. Potter, R. Ravindrarajah, P. Whittaker, C. Widden, D. Withers, N. J. Cardin, T. Ferreira, J. Pereira-Gale, I. B. Hallgrimsdottir, B. N. Howie, Z. Su, Y. Y. Teo, D. Vukcevic, D. Bentley, A. Compston, N. J. Ouwehand, M. R. Samani, J. D. Isaacs, A. W. Morgan, G. D. Wilson, A. Ardern-Jones, J. Berg, A. Brady, Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes Science. ,vol. 316, pp. 1336- 1341 ,(2007) , 10.1126/SCIENCE.1142364
Robert H Eckel, KGMM Alberti, Scott M Grundy, Paul Z Zimmet, The metabolic syndrome The Lancet. ,vol. 365, pp. 1415- 1428 ,(2005) , 10.1016/S0140-6736(09)61794-3
Sebastiaan Hammer, Marieke Snel, Hildo J. Lamb, Ingrid M. Jazet, Rutger W. van der Meer, Hanno Pijl, Edo A. Meinders, Johannes A. Romijn, Albert de Roos, Johannes W.A. Smit, Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. Journal of the American College of Cardiology. ,vol. 52, pp. 1006- 1012 ,(2008) , 10.1016/J.JACC.2008.04.068
Marijke Smit, Peter de Knijff, Maryvonne Rosseneu, Jo Bury, Eduard Klasen, Rune Frants, Louis Havekes, Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels Human Genetics. ,vol. 80, pp. 287- 292 ,(1988) , 10.1007/BF01790099
György Csaba, Péter Kovács, EFFECT OF NEONATAL INTERLEUKIN-6 (IL-6) TREATMENT (HORMONAL IMPRINTING) ON THE IL-6 CONTENT AND LOCALIZATION OF THE PERITONEAL, BLOOD AND THYMIC CELLS OF ADULT RATS. A CONFOCAL MICROSCOPIC ANALYSIS Cell Biology International. ,vol. 25, pp. 1179- 1182 ,(2001) , 10.1006/CBIR.2001.0782
G. FEUSSNER, H. FUNKE, W. WENG, G. ASSMANN, K. J. LACKNER, R. ZIEGLER, Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and & epsilon;1/lsquo;null genotype‡ European Journal of Clinical Investigation. ,vol. 22, pp. 599- 608 ,(1992) , 10.1111/J.1365-2362.1992.TB01511.X
Yurii S Aulchenko, Maksim V Struchalin, Nadezhda M Belonogova, Tatiana I Axenovich, Michael N Weedon, Albert Hofman, Andre G Uitterlinden, Manfred Kayser, Ben A Oostra, Cornelia M van Duijn, A Cecile J W Janssens, Pavel M Borodin, Predicting human height by Victorian and genomic methods. European Journal of Human Genetics. ,vol. 17, pp. 1070- 1075 ,(2009) , 10.1038/EJHG.2009.5