Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

作者: N. Bradshaw , C. Brewer , G. Brice , B. Bullman , J. Campbell

DOI: 10.1126/SCIENCE.1142364

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摘要: … 8). This T2D-specific data set shows no evidence of substantial confounding from population substructure and genotyping biases (8… validation genotyping on a second platform (8). Next, …

参考文章(24)
David Altshuler, Joel N. Hirschhorn, Mia Klannemark, Cecilia M. Lindgren, Marie-Claude Vohl, James Nemesh, Charles R. Lane, Stephen F. Schaffner, Stacey Bolk, Carl Brewer, Tiinamaija Tuomi, Daniel Gaudet, Thomas J. Hudson, Mark Daly, Leif Groop, Eric S. Lander, The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics. ,vol. 26, pp. 76- 80 ,(2000) , 10.1038/79216
Sushil G. Rane, Pierre Dubus, Richard V. Mettus, Elizabeth J. Galbreath, Guenther Boden, E. Premkumar Reddy, Mariano Barbacid, Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nature Genetics. ,vol. 22, pp. 44- 52 ,(1999) , 10.1038/8751
Struan F A Grant, Gudmar Thorleifsson, Inga Reynisdottir, Rafn Benediktsson, Andrei Manolescu, Jesus Sainz, Agnar Helgason, Hreinn Stefansson, Valur Emilsson, Anna Helgadottir, Unnur Styrkarsdottir, Kristinn P Magnusson, G Bragi Walters, Ebba Palsdottir, Thorbjorg Jonsdottir, Thorunn Gudmundsdottir, Arnaldur Gylfason, Jona Saemundsdottir, Robert L Wilensky, Muredach P Reilly, Daniel J Rader, Yu Bagger, Claus Christiansen, Vilmundur Gudnason, Gunnar Sigurdsson, Unnur Thorsteinsdottir, Jeffrey R Gulcher, Augustine Kong, Kari Stefansson, Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nature Genetics. ,vol. 38, pp. 320- 323 ,(2006) , 10.1038/NG1732
Karen A. Seta, Richard A. Roth, Overexpression of insulin degrading enzyme: cellular localization and effects on insulin signaling. Biochemical and Biophysical Research Communications. ,vol. 231, pp. 167- 171 ,(1997) , 10.1006/BBRC.1997.6066
Simon Myers, Leonardo Bottolo, Colin Freeman, Gil McVean, Peter Donnelly, A Fine-Scale Map of Recombination Rates and Hotspots Across the Human Genome Science. ,vol. 310, pp. 321- 324 ,(2005) , 10.1126/SCIENCE.1117196
Roque Bort, Juan Pedro Martinez-Barbera, Rosa SP Beddington, Kenneth S Zaret, Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. ,vol. 131, pp. 797- 806 ,(2004) , 10.1242/DEV.00965
Wesley Farris, Stefan Mansourian, Malcolm A Leissring, Elizabeth A Eckman, Lars Bertram, Christopher B Eckman, Rudolph E Tanzi, Dennis J Selkoe, None, Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein American Journal of Pathology. ,vol. 164, pp. 1425- 1434 ,(2004) , 10.1016/S0002-9440(10)63229-4
Mariano Ubeda, J. Michael Rukstalis, Joel F. Habener, Inhibition of Cyclin-dependent Kinase 5 Activity Protects Pancreatic Beta Cells from Glucotoxicity Journal of Biological Chemistry. ,vol. 281, pp. 28858- 28864 ,(2006) , 10.1074/JBC.M604690200
Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui, Kazuhito Tomizawa, Cdk5-dependent regulation of glucose-stimulated insulin secretion Nature Medicine. ,vol. 11, pp. 1104- 1108 ,(2005) , 10.1038/NM1299