Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.
作者： Roberto Vettor , Marnie Granzotto , Diego De Stefani , Elisabetta Trevellin , Marco Rossato
DOI: 10.1210/JC.2007-2680
关键词: Secretion 、 Receptor 、 Body mass index 、 Biology 、 Internal medicine 、 Calcium in biology 、 Endocrinology 、 Insulin 、 Glucose homeostasis 、 Free fatty acid receptor 1 、 Pancreatic hormone
摘要: Background: Free fatty acids (FFAs) acutely stimulate but chronically impair glucose-stimulated insulin secretion from β-cells. The G protein-coupled transmembrane receptor 40 (GPR40) mediates both acute and chronic effects of FFAs on plays a role in glucose homeostasis. Limited information is available the effect GPR40 genetic abnormalities metabolic regulation human subjects. Study Design Results: For vivo studies, we screened 734 subjects for coding region identified new single-nucleotide mutation (Gly180Ser). mean allele frequency was 0.75%, which progressively increased (P < 0.05) nonobese (0.42%) to moderately obese (body mass index = 30–39.9 kg/m2, 1.07%) severely patients ≥ 2.60%). relationship between mutation, secretion, alterations studied 11 Gly/Ser carriers. In these subjects, (insulinogen...
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