Brain Tumors: Diagnostic Impact of PET Using Radiolabelled Amino Acids

摘要: Magnetic resonance tomography (MRT) allows an exact morphologic visualisation of the brain and is investigation choice for diagnosing cerebral glioma, but its capacity to differentiate tumor tissue from non-specific changes limited. Positron emission (PET) using radiolabeled amino acids provides additional metabolic information which helps increase diagnostic accuracy. The use better delineation margins improves targeting biopsy radiotherapy, planning surgery. In addition, acid imaging appears useful in distinguishing recurrence post-therapeutic edema scar tissue, predicting prognosis low grade gliomas, monitoring response during treatment. Most PET studies gliomas have been performed with 11C-methyl-L-methionine (MET), although short half-life 11C (20 min) limits this technique few centers that are equipped in-house cyclotron facility. recent years 18F-labelled (half-life 109 such as O-(2-[18F]fluoroethyl)-L-tyrosine (FET) developed allow a more widespread imaging. logistical prerequisites tumors become markedly less difficult introduction like FET. scientifically documented utility justifies routine certain indications.