Patterns of autoimmunity to nucleoproteins in patients with systemic lupus erythematosus.

摘要: The ANAs described above can be accounted for on the basis of an immune response to just three nucleoprotein structures--the nucleosome, U1 snRNP, and Ro particle. When these nucleoproteins are looked at in turn, following picture emerges. nucleosome is identified by both anti-histone anti-DNA antibodies. Anti-histone H1 H2B antibodies predominate tend occur together. They, as well with which they appear linked, recognize external features intact nucleosome. snRNP recognized anti-U1 RNP anti-Sm Most so-called antisera actually contain several linked sets different that directed against various polypeptides (68K, A, C) found snRNP. Anti-Sm occurrence particle anti-La anti-Ro antibodies, almost all sera also Thus, it appears particles become direct focal points autoimmune responses SLE. It difficult explain such focused a general defect regulation or spontaneous B-lymphocyte hyperactivity. Rather themselves directly involved determining clones activated. simplest rationalization patterns autoantibodies invoke possibility triggering responses.