Systematic review of evidence and consensus on perianal fistula: an analysis of national and international guidelines.

摘要: Aim Treatment of perianal fistula has evolved with the introduction new techniques and biologicals in Crohn's disease (CD). Several guidelines are available worldwide, but many recommendations controversial or lack high-quality evidence. The aim this work was to provide an overview current national international for analyse areas consensus conflicting recommendations, thereby identifying topics questions future research. Method MEDLINE, EMBASE PubMed were systematically searched on fistula. Inclusion limited papers English less than 10 years old. included classified as having (unanimous at least two-thirds guidelines) controversy (fewer three commenting topic no consensus) between guidelines. highest level evidence scored sufficient (level 3a higher Oxford Centre Evidence-based Medicine Levels Evidence 2009, http://www.cebm.net/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/) insufficient. Results Twelve compared. Overall, present 15 topics, whereas six rated controversial. levels varied from strong evidence. Conclusion Evidence diagnosis treatment fistulae (cryptoglandular related CD) ranged nonexistent strong, regardless consensus. most relevant research were identified proposed research.