Long term (five-year) survival following radical surgical treatment plus adjuvant chemotherapy (FAM) in advanced gastric cancer: a controlled study

摘要: Several drugs and their associations are being used for adjuvant or complementary chemotherapy with the aim of improving results gastric cancer treatment. The objective this study was to verify impact these on nutrition survival rate after radical treatment 53 patients in stage III TNM classification. A control group including 28 who had only undergone resection compared a 25 underwent same operative technique followed by polychemotherapy FAM (5-fluorouracil, Adriamycin, mitomycin C). In latter group, toxicity relation hepatic, renal, cardiologic, neurological, hematologic, gastrointestinal, dermatological functions also studied. There no significant difference admission between both groups gender, race, macroscopic tumoral type tumor according Borrmann classification, location stomach, length resection, response cutaneous tests delayed sensitivity. Chemotherapy started average, 2.3 months following surgical Clinical laboratory follow-up all continued 5 years. conclusions were reached: 1) nutritional status incidence gastrointestinal manifestation similar groups; 2) occurrence cardiac, hepatic death due chemotherapeutic method per se; 3) Dermatological alterations hematological occurred exclusively polychemotherapy; 4) site recurrence, disease-free interval, 5) Therefore, we concluded, 5-year follow-up, regimen did not increase rate.