Becoming glial in the neural retina.

摘要: During development of the vertebrate neural retina, multipotent stem cells give rise to retinal neurons as well Muller cells, principal glial population in retina. Recent studies have shed light upon extracellular and intracellular signaling pathways that regulate cell genesis. Emerging evidence demonstrates activation Notch pathway can play a role regulating gliogenesis other parts central nervous system. Cyclin dependent kinase (CDK) inhibitors Cip/Kip subfamily are cycle regulators progenitor proliferation during development, but also glia when they become activated response stress or injury. Surprisingly this class proteins promote glia. In review we discuss both CDK development. © 2001 Wiley-Liss, Inc.