Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.

摘要: Infection of human epidermoid carcinoma No. 2 cells with herpes simplex virus type 1 (HSV-1) leads to a reorganization antigens associated both the small and heterogeneous nuclear ribonucleoprotein complexes (snRNP hnRNP). The hnRNP core protein remain host chromatin, which appears collapse into internal aggregates along envelope. More striking is formation prominent clusters snRNP (both general U1 specific), appear condense throughout nucleus then migrate periphery. These have been identified at fine structure level by immuno-electron microscopy. HSV-1 presumed transcriptional activator ICP4, DNA-binding ICP8, two capsid proteins ICP5 p40 are not detectably clusters. Similar occurs HSV-2 upon infection African green monkey VERO HSV-1. We speculate that arise from an increase in size density interchromatin granule region cell as result partial inactivation pre-mRNA splicing.