Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression.

作者： Elliott H. Sohn , Tami Wolden-Hanson , Alvin M. Matsumoto

关键词: Endocrinology 、 Internal medicine 、 Gene expression 、 In situ hybridization 、 Neuropeptide 、 Biology 、 Cart 、 Amphetamine 、 Castration 、 Orchiectomy 、 Messenger RNA

摘要: The age-related decrease in serum T levels is associated with impairments food intake and weight regulation alterations brain peptides that regulate energy balance. To test the hypothesis reduced contribute to altered hypothalamic cocaine-amphetamine-regulated transcript (CART) NPY gene expression, mRNA content of these neuropeptides was measured by situ hybridization sham-operated (intact), castrated, T-replaced castrated young old male Brown Norway rats. rats were similar those intact animals. Compared rats, arcuate nucleus CART lower higher both animals, suggesting reciprocal T; T-induced changes localized primarily rostral markedly attenuated paraventricular animals We conclude neurons remain responsive albeit less so than reduction contributes part neuropeptide expression favoring anorexia wasting aging.

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Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression.

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Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression.

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