Trapping-free parp inhibitors
作者： Chuo Chen , Yonghao Yu , Lei Han , Lin You , Shuai Wang
DOI:
关键词: Selective degradation 、 Protein level 、 Poly ADP ribose polymerase 、 Chemistry 、 PARP inhibitor 、 Cell biology 、 Ubiquitin ligase
摘要: The disclosure provides PARP PROTAC molecules comprising a inhibitor linked to an E3 ligase binder, and their use in treating diseases caused by aberrant activation. Such produce selective degradation of one or specific set proteins with limited effects on the protein level other PARPs.
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