Synergistic effect of anti-trop-2 antibody-drug conjugate in combination therapy for triple-negative breast cancer when used with microtubule inhibitors or parp inhibitors

作者: Thomas M. Cardillo , David M. Goldenberg

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摘要: The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, microtubule inhibitors and/or PARP inhibitors. Where are used, they preferably incorporate SN-38 or another drug that induces DNA strand breaks. Preferably, the of ADC PARPi inhibitor exhibits synergistic effects cancer. can reduce solid tumors in size, eliminate metastases is effective treat cancers resistant standard therapies, radiation therapy, chemotherapy immunotherapy.

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