Sepsis-related anemia in a pediatric intensive care unit: transfusion-associated outcomes.

摘要: BACKGROUND Pediatric patients with sepsis in intensive care units are at high risk of developing anemia, which might have adverse effects on their prognosis. This study aimed to evaluate the impact red blood cell (RBC) transfusion outcomes admitted a pediatric unit (PICU) sepsis. METHODS We conducted prospective randomized clinical trial, enrolling 67 children, aged 2 144 months who were PICU new episode from November 2017 April 2018. Patients allocated randomly two groups: Group 1, liberal strategy group, including 33 had initial hemoglobin (Hb) between 7 or greater and less than 10 g/dL received an RBC top-up 12 g/dL; 2, restrictive 34 same Hb range did not receive RBCs. Hb less excluded. RESULTS Of transfusions, 31 (93.94%) required ventilation, 29 (87.88%) multiorgan dysfunction. They significantly lengthier hospital stay higher incidence acute respiratory distress syndrome lung injury. Moreover, mortality was group (42.4% vs. 17.6%). CONCLUSIONS Compared strategy, be associated worse outcome. However, possible role other known unknown confounding factors minor protocol violations should taken into consideration. recommend minimizing worsening anemia reduce need for transfusion.