The acute immunological response to blood transfusion is influenced by polymicrobial sepsis

摘要: Blood transfusion is a well-established risk factor for adverse outcomes during sepsis. The specific mechanisms responsible this effect remain elusive, and few studies have investigated phenomenon in model that reflects not only the clinical circumstances which blood transfused, but also how packed red cells (PRBCs) are created stored. Using cecal ligation puncture of polymicrobial sepsis as well creating murine allogeneic stored PRBCs manner replicates process, we demonstrated induces numerous effects on leukocyte subpopulations. In sepsis, these responses profoundly dissimilar to proinflammatory PRBC observed healthy mouse. Transfused septic mice, opposed mice receiving crystalloid resuscitation, had significant loss blood, spleen, bone marrow lymphocytes, especially those with an activated phenotype. Myeloid behaved similarly, although they were able produce more reactive oxygen species. Overall, mouse may contribute persistent immune dysfunction known be associated rather than simply promote or anti-inflammatory host. Thus, it possible contributes multiple populations been shown result increased morbidity mortality.