Anesthetic blocking of nerve membrane conductances by internal and external applications.
作者： Toshio Narahashi , John W. Moore , Robin N. Poston
关键词: Biology 、 Conductance 、 Biophysics 、 Pentobarbital 、 Anesthetic 、 Depolarization 、 Anesthesia 、 Tropine 、 Membrane potential 、 Dibucaine 、 Tetrodotoxin
摘要: Dibucaine hydrochloride, pentobarbital sodium, tropine p-tolyl acetate hydrochloride (tertiary form), and methiodide (quaternary form) reversibly blocked both peak transient steadystate components of conductance changes from either side the squid nerve membrane. With external internal applications dibucaine with application tertiary topine, steady-state current declined somewhat, leaving a “hump.” The time to early was unaffected by or dibucaine, but prolonged pentobarbital. curve relating membrane potential shifted along axis in direction depolarization It is suggested that mechanism blockage these anesthetic agents different tetrodotoxin uncharged lipid-soluble chemicals.
sci-hub.se 参考文章(31)
Clay M. Armstrong, Leonard Binstock, THE EFFECTS OF SEVERAL ALCOHOLS ON THE PROPERTIES OF THE SQUID GIANT AXON. The Journal of General Physiology. ,vol. 48, pp. 265- 277 ,(1964) , 10.1085/JGP.48.2.265
Bertil Hille, The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion The Journal of General Physiology. ,vol. 50, pp. 1287- 1302 ,(1967) , 10.1085/JGP.50.5.1287
T. Narahashi, N. C. Anderson, J. W. Moore, Tetrodotoxin does not block excitation from inside the nerve membrane. Science. ,vol. 153, pp. 765- 767 ,(1966) , 10.1126/SCIENCE.153.3737.765
S.L. Friess, R.C. Durant, H.L. Martin, Potency convergence and crossover in tertiary vs. quaternary tropine amino esters Toxicology and Applied Pharmacology. ,vol. 9, pp. 240- 256 ,(1966) , 10.1016/0041-008X(66)90119-0
M. Takata, J. W. Moore, C. Y. Kao, F. A. Fuhrman, Blockage of Sodium Conductance Increase in Lobster Giant Axon by Tarichatoxin (Tetrodotoxin) The Journal of General Physiology. ,vol. 49, pp. 977- 988 ,(1966) , 10.1085/JGP.49.5.977
M. P. Blaustein, D. E. Goldman, Action of anionic and cationic nerve-blocking agents: experiment and interpretation. Science. ,vol. 153, pp. 429- 432 ,(1966) , 10.1126/SCIENCE.153.3734.429
Toshio Narahashi, Nels C. Anderson, Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons Toxicology and Applied Pharmacology. ,vol. 10, pp. 529- 547 ,(1967) , 10.1016/0041-008X(67)90092-0
M. P. Blaustein, Action of Certain Tropine Esters on Voltage-Clamped Lobster Axon The Journal of General Physiology. ,vol. 51, pp. 309- 319 ,(1968) , 10.1085/JGP.51.3.309
G. Camougis, B. H. Takman, J. Rene, P. Tasse, Potency difference between the zwitterion form and the cation forms of tetrodotoxin. Science. ,vol. 156, pp. 1625- 1627 ,(1967) , 10.1126/SCIENCE.156.3782.1625
D. E. Goldman, M. P. Blaustein, Ions, drugs and the axon membrane. Annals of the New York Academy of Sciences. ,vol. 137, pp. 967- 981 ,(1966) , 10.1111/J.1749-6632.1966.TB50210.X