The effects of prostaglandin E1 on the adult respiratory distress syndrome in septic primates.
作者： Douglas C. Brockmann , John H. Stevens , Peter O'Hanley , Jeffrey Shapiro , Clark Walker
DOI: 10.1164/ARRD.1986.134.5.885
关键词: Respiratory distress 、 Prostaglandin E1 、 Respiratory disease 、 Surgery 、 Cardiac output 、 Vascular resistance 、 Anesthesia 、 Blood pressure 、 Septic shock 、 Hemodynamics 、 Medicine
摘要: The effects of prostaglandin E1 (PGE1 on the adult respiratory distress syndrome were studied in septic primate ( Macaca fascicularis). A 30-min infusion Escherichia coli (1 × 1010/kg) resulted severe shock and syndrome. Primates, if living, killed 4 h after completion E. infusion. Three groups primates (n = each group). control group (Group 1) received PGE1 at 100 ng/kg/min throughout experiment. 2) a . treatment 3) continuous (100 ng/kg/min) along with which was begun 30 min started. Control had hemodynamic changes consistent vasodilatory effect (heart rate cardiac output increased; blood pressure systemic vascular resistance (SVR) decreased). All animals survived experiment no evidence pulmonary damage. Primat...
sci-hub.se 参考文章(30)
W. A. Marasco, L. J. Elgas, J. C. Fantone, P. A. Ward, Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production. American Journal of Pathology. ,vol. 115, pp. 9- 16 ,(1984)
R B Zurier, P A Ward, J C Fantone, S L Kunkel, Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators. Journal of Immunology. ,vol. 125, pp. 2591- 2596 ,(1980)
Lars A. Carlson, Lars-Göran Ekelund, Lars Orö, CLINICAL AND METABOLIC EFFECTS OF DIFFERENT DOSES OF PROSTAGLANDIN E1 IN MAN Acta Medica Scandinavica. ,vol. 183, pp. 423- 430 ,(2009) , 10.1111/J.0954-6820.1968.TB10502.X
R A Hull, R E Gill, P Hsu, B H Minshew, S Falkow, Construction and expression of recombinant plasmids encoding type 1 or D-mannose-resistant pili from a urinary tract infection Escherichia coli isolate. Infection and Immunity. ,vol. 33, pp. 933- 938 ,(1981) , 10.1128/IAI.33.3.933-938.1981
G O Till, K J Johnson, R Kunkel, P A Ward, Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites. Journal of Clinical Investigation. ,vol. 69, pp. 1126- 1135 ,(1982) , 10.1172/JCI110548
Thomas L. Petty, David G. Ashbaugh, The Adult Respiratory Distress Syndrome: Clinical Features, Factors Influencing Prognosis and Principles of Management Chest. ,vol. 60, pp. 233- 239 ,(1971) , 10.1378/CHEST.60.3.233
J R Snapper, J M Hinson, A A Hutchison, P L Lefferts, M L Ogletree, K L Brigham, Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia. Journal of Clinical Investigation. ,vol. 74, pp. 1782- 1791 ,(1984) , 10.1172/JCI111597
Michael E. Smith, Prostaglandin Infusion and Endotoxin-Induced Lung Injury Archives of Surgery. ,vol. 117, pp. 175- 180 ,(1982) , 10.1001/ARCHSURG.1982.01380260045008
Frederick G. Mihm, Thomas W. Feeley, Myer H. Rosenthal, Frank Lewis, Measurement of extravascular lung water in dogs using the thermal-green dye indicator dilution method. Anesthesiology. ,vol. 57, pp. 116- 122 ,(1982) , 10.1097/00000542-198208000-00009
J H Stevens, P O'Hanley, J M Shapiro, F G Mihm, P S Satoh, J A Collins, T A Raffin, Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. Journal of Clinical Investigation. ,vol. 77, pp. 1812- 1816 ,(1986) , 10.1172/JCI112506