Adhesive Events in Retinal Development and Function: The Role of Integrin Receptors

摘要: Cells in the developing retina contact a vast array of molecular cues their microenvironment that are thought to guide development. Many these embedded surface neighboring cells or deposited within extracellular matrix (ECM). Evidence has accumulated cell-cell and cell-ECM interactions essential many phases neural development, including neuroblast migration, determination cell fate, axon outgrowth synapse formation. In this chapter, we examine developmental functional roles fulfilled by integrins, family receptors for ECM molecules adhesion (CAMs). We have approached problem addressing series three questions: (1) which integrins expressed retina? (2) when where they expressed? and, (3) what functions do carry out? Integrins previously been implicated extension, but new evidence suggests also involved earlier events preaxonal neuroblasts. High levels expression at least eight integrin subunits documented young retinal cells, containing β1 subunit migration adolescent ganglion cells. Integrin persists through adulthood, both layer pigment epithelium (RPE). The αvβ5 shown reside on apical RPE phagocytosis shed photoreceptor outer segments.