Three vs. 10 days of amoxycillin–clavulanic acid for type 1 acute exacerbations of chronic obstructive pulmonary disease: a randomised, double-blind study

摘要: ABSTRACT The optimal duration of antibiotic treatment for acute exacerbations chronic obstructive pulmonary disease (AECOPD) is unknown. This study compared the outcome 3 vs. 10 days with amoxycillin–clavulanic acid hospitalised patients AECOPD who had improved substantially after initial therapy days. Between November 2000 and December 2003, 56 were enrolled in study. Unfortunately, because low inclusion rate, trial was discontinued prematurely. Patients treated oral or intravenous acid. showed improvement 72 h randomised to receive 625 mg placebo, four times daily 7 primary measure clinical cure weeks months. Of 46 included final analysis, 21 3-day group 25 10-day group. After weeks, 16 (76%) cured, 20 (80%) (difference –3.8%; 95% CI –28 20). months, 13 (62%) 14 (56%) 5.9%; –23 34). Microbiological success, symptom recovery, use corticosteroids, oxygen length hospital stay comparable both groups. It concluded that can be a safe effective alternative standard have