Introduction: standards of antibacterial performance

摘要: The development and clinical use of antimicrobial agents continue to evolve in line with new science, understanding needs. While resistance remains an important determinant for drug therapeutic choice, pharmacokinetic pharmacodynamic parameters are having ever-increasing importance defining performance targets established agents. Recently licensed therapies largely directed at serious hospital-associated Gram-positive infections, whereas the community, choice dependent on well-established from limited classes antimicrobials. In order maximise benefits such agents, it is appropriate that dosage regimens antibacterial choices be reviewed light knowledge, particularly area pharmacokinetics pharmacodynamics. Antimicrobial continues evolve, notably within respiratory pathogens, therefore steps must taken maintain optimum outcomes also limit spread resistant strains. Whilst changes patient physician attitudes behaviour towards better quality prescribing important, developed provide adequate coverage pathogens. Development times novel antimicrobials long, uncertain safety profiles chances success. Thus, formulations existing designed overcome current patterns, constitutes a potentially additional strategy prescribing.