Acute and chronic neuroborreliosis with and without CNS involvement: a clinical, MRI, and HLA study of 27 cases.
作者： E. Heim , B. Schuknecht , S. Scholz , H. Krüger
DOI: 10.1007/BF00319739
关键词: Doxycycline 、 Central nervous system 、 Medicine 、 Neuroborreliosis 、 Cortisone 、 Neurology 、 Spinal cord 、 Neuroradiology 、 Magnetic resonance imaging 、 Pathology
摘要: Of the 96 serologically confirmed neuroborreliosis cases seen in our clinic between 1983 and 1988, 11 patients had mild to moderate 4 serious cerebral and/or spinal cord symptoms. Nine of these 15 with CNS involvement exhibited a primary chronic course illness. After high-dose intravenous therapy penicillin, doxycycline or cefotaxime, given mostly combination cortisone, gradual recovery occurred normalization CSF findings characteristic neuroborreliosis, significantly elevated Borrelia burgdorferi IgG antibody titres serum. Brain MRI CT showed evidence were suggestive vascular which correlated clinical symptoms involvement. changes that similar but much slighter number intensity 5 12 without signs (lymphocytic meningoradiculitis; Bannwarth's syndrome). The frequencies HLA-DR7 (75%), HLA-B44 (50%) HLA-A29 (33%) antigens different from 100 control subjects. Diagnostic criteria active are proposed.
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sci-hub.se 参考文章(55)
H. Krüger, R. Martin, V. Sticht-Groh, M. Pulz, Long-term persistence of specific T- and B-lymphocyte responses to Borrelia burgdorferi following untreated neuroborreliosis. Infection. ,vol. 18, pp. 263- 267 ,(1990) , 10.1007/BF01646998
G. Schaltenbrand, Durch Arthropoden übertragene Erkrankungen der Haut und des Nervensystems Verhandlungen der Deutschen Gesellschaft für Innere Medizin. pp. 975- 1005 ,(1967) , 10.1007/978-3-642-96034-5_169
G T Stiernstedt, M Granström, B Hederstedt, B Sköldenberg, Diagnosis of spirochetal meningitis by enzyme-linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. Journal of Clinical Microbiology. ,vol. 21, pp. 819- 825 ,(1985) , 10.1128/JCM.21.5.819-825.1985
L A Magnarelli, J M Meegan, J F Anderson, W A Chappell, Comparison of an indirect fluorescent-antibody test with an enzyme-linked immunosorbent assay for serological studies of Lyme disease. Journal of Clinical Microbiology. ,vol. 20, pp. 181- 184 ,(1984) , 10.1128/JCM.20.2.181-184.1984
K. Bukasa, Geoffroy Bigaignon, Christian Sindic, C. Laterre, A Depré, Formes encéphalomyélitiques de l'infection a Borrelia burgdorferi. Revue Neurologique. ,vol. 144, pp. 416- 420 ,(1988)
W. Kristoferitsch, W. R. Mayr, HLA-DR in meningopolyneuritis of garin-bujadoux-bannwarth: contrast to lyme disease? Journal of Neurology. ,vol. 231, pp. 271- 272 ,(1984) , 10.1007/BF00313666
J. J. Halperin, L. B. Krupp, M. G. Golightly, D. J. Volkman, Lyme borreliosis‐associated encephalopathy Neurology. ,vol. 40, pp. 1340- 1340 ,(1990) , 10.1212/WNL.40.9.1340
JOSEPH P. BRODERICK, BURTON A. SANDOK, LESTER E. MERTZ, Focal encephalitis in a young woman 6 years after the onset of Lyme disease: Tertiary Lyme disease? Mayo Clinic Proceedings. ,vol. 62, pp. 313- 316 ,(1987) , 10.1016/S0025-6196(12)61910-7
A. R. Pachner, P. Duray, A. C. Steere, Central nervous system manifestations of Lyme disease. JAMA Neurology. ,vol. 46, pp. 790- 795 ,(1989) , 10.1001/ARCHNEUR.1989.00520430086023
R. Dörries, V. Ter Meulen, Detection and identification of virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid by immunoblot technique Journal of Neuroimmunology. ,vol. 7, pp. 77- 89 ,(1984) , 10.1016/S0165-5728(84)80008-9