The effect of inhaled fluticasone propionate in the treatment of young asthmatic children: a dose comparison study.
作者： HANS BISGAARD , JOHN GILLIES , MARCELLE GROENEWALD , CLAIRE MADEN
DOI: 10.1164/AJRCCM.160.1.9811024
关键词: Inhaler 、 Asthma 、 Anesthesia 、 Exacerbation 、 Corticosteroid 、 Fluticasone 、 Medicine 、 Placebo 、 Fluticasone propionate 、 Randomized controlled trial
摘要: The response in asthmatic young children to inhaled steroids within the usual pediatric dose range is unknown. We therefore evaluated dose-related with moderate asthma fluticasone propionate (FP) (delivered via Babyhaler spacer device) range. A total of 237 (mean age 28 mo, 12 47) symptoms were studied this multicenter, randomized, double-blind, parallel group, placebocontrolled study wk treatment following a 4-wk run-in period. median use rescue medication was 1 2 d during FP 50 m g twice daily (FP100) and 100 (FP200) compared placebo from pressurized metered-dose inhaler (pMDI) device. With FP200 there statistically significant improvement baseline, as 8 10 diary card parameters, including three symptom domains wheeze, cough, breathlessness, medication. FP100 produced reduction 5 these whereas no differences found between FP100. numbers patients at least one exacerbation placebo, FP100, 37%, 26%, 20%, respectively. This difference FP200, well order (p , 0.05). Both doses tolerated over similar incidence adverse effects. Asthmatic 1- 3-yr-old responded manner Bisgaard H, Gillies J, Groenewald M, Maden C on behalf an International Study Group. effect children: comparison study. AM J RESPIR CRIT CARE MED 1999;160:126‐131.
sci-hub.se 参考文章(14)
Jorrit Gerritsen, Gerard H. Koëter, Dirkje S. Postma, Jan P. Schouten, Klaas Knol, Prognosis of Asthma from Childhood to Adulthood The American review of respiratory disease. ,vol. 140, pp. 1325- 1330 ,(1989) , 10.1164/AJRCCM/140.5.1325
G J Connett, C Warde, E Wooler, W Lenney, Use of budesonide in severe asthmatics aged 1-3 years. Archives of Disease in Childhood. ,vol. 69, pp. 351- 355 ,(1993) , 10.1136/ADC.69.3.351
MJA Tasche, JC van der Wouden, JHJM Uijen, BP Ponsioen, RMD Bernsen, LWA van Suijlekom-Smit, JC de Jongste, Randomised placebo-controlled trial of inhaled sodium cromoglycate in 1-4-year-old children with moderate asthma. The Lancet. ,vol. 350, pp. 1060- 1064 ,(1997) , 10.1016/S0140-6736(97)05333-6
Fernando D. Martinez, Anne L. Wright, Lynn M. Taussig, Catharine J. Holberg, Marilyn Halonen, Wayne J. Morgan, Asthma and wheezing in the first six years of life. The Group Health Medical Associates. The New England Journal of Medicine. ,vol. 332, pp. 133- 138 ,(1995) , 10.1056/NEJM199501193320301
Michael Silverman, Childhood asthma and other wheezing disorders Arnold. ,(1995)
Fernando D Martinez, Wayne J Morgan, Anne L Wright, Catharine J Holberg, Lynn M Taussig, Group Health Medical Associates' Personnel*, None, Diminished Lung Function as a Predisposing Factor for Wheezing Respiratory Illness in Infants New England Journal of Medicine. ,vol. 319, pp. 1112- 1117 ,(1988) , 10.1056/NEJM198810273191702
N M Wilson, M Silverman, Treatment of acute, episodic asthma in preschool children using intermittent high dose inhaled steroids at home. Archives of Disease in Childhood. ,vol. 65, pp. 407- 410 ,(1990) , 10.1136/ADC.65.4.407
N Wilson, K Sloper, M Silverman, Effect of continuous treatment with topical corticosteroid on episodic viral wheeze in preschool children. Archives of Disease in Childhood. ,vol. 72, pp. 317- 320 ,(1995) , 10.1136/ADC.72.4.317
Hans Bisgaard, Systemic activity of inhaled topical steroid in toddlers studied by knemometry. Acta Paediatrica. ,vol. 82, pp. 1066- 1071 ,(1993) , 10.1111/J.1651-2227.1993.TB12814.X
R DODGE, F MARTINEZ, M CLINE, M LEBOWITZ, B BURROWS, Early childhood respiratory symptoms and the subsequent diagnosis of asthma. The Journal of Allergy and Clinical Immunology. ,vol. 98, pp. 48- 54 ,(1996) , 10.1016/S0091-6749(96)70225-7