Melanin biosynthesis inhibitors from the bark of Machilus thunbergii.
作者： Gao Li , Hye Kyung Ju , Hyuen Wook Chang , Yurngdong Jahng , Seung-Ho Lee
DOI: 10.1248/BPB.26.1039
关键词: Biosynthesis 、 Bark 、 Melanin 、 Fractionation 、 IC50 、 Biology 、 Methylene 、 Lauraceae 、 Biochemistry 、 Lignan
摘要: The bioassay-guided fractionation of the methylene chloride soluble portion a methanol extract Machilus thunbergii bark led to isolation four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin (3) and B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC50: 39.9, 15.1, 19.4 37.8 μM, respectively).
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