Postchemoradiotherapy Positron Emission Tomography Predicts Pathologic Response and Survival in Patients With Esophageal Cancer

摘要: Purpose To correlate the prechemoradiotherapy (CRT) and post-CRT metabolic tumor volume (MTV) on positron emission tomography (PET) scanning with pathologic response survival in patients receiving preoperative CRT for esophageal cancer. Materials Methods The medical records of 37 histologically confirmed Stage I–IVA cancer treated or without surgical resection were reviewed. Of patients, 21 received (57%) 16 definitive (43%). All had a pre-CRT 32 PET scan. MTV was measured scan, respectively, using minimum standardized uptake value (SUV) threshold x, where x=2, 2.5, 3, SUV maximum × 50%. total glycolytic activity (TGA x ) defined as mean . ratio MTV/post-CRT MTV. similarly. A single pathologist scored regression grade (TRG) scale. Results median follow-up 1.5 years (range, 0.4–4.9). No significant correlation found between any parameters scan TRG overall (OS). Multiple values post-TGA correlated OS; however, 2.5Post TGA greatest correlation. 2 OS. either scans did not Patients preoperatively similar compared those definitively good ( p = 0.97) significantly better than that poor Conclusion predictive prognostic parameter. 2.5 useful markers predicting also survival. Post-CRT can potentially guide therapy after CRT.