18-fluorodeoxy-glucose positron emission computed tomography as predictive of response after chemoradiation in oesophageal cancer patients

摘要: Abstract Introduction The purpose of this study was to evaluate if a baseline, an interim or post-chemoradiation (CTRT) 18-fluorodeoxy-glucose positron emission computed tomography (18F-FDG PET/CT) studies could provide information on pathologic response CTRT and overall survival (OS). Materials methods Thirty-one patients with histologically proven adenocarcinoma squamous cell carcinoma the oesophagus, fit for trimodality therapy were prospectively enrolled. Most men (93.5%), had stage III cancer (74.2%). Chemotherapy consisted oxaliplatin/5-fluorouracil (45.2%) taxane/5-fluorouracil (54.8%). All underwent (performed 12 ± 2 days after onset CTRT) post-CTRT 18F-FDG PET/CT study. variables evaluated at maximum standardised uptake value (SUVmax) total lesion glycolysis (TLG). Clinical parameters correlated complete (pathCR) OS. Results Among 31 studied, 61.3% achieved clinical (cCR) 87.1% surgery. median OS 35.1 months (95% confidence interval (CI): 19.9–NA). PathCR rate 22.2%. There only marginal association between cCR pathCR ( p  = 0.06). None other predictive pathCR. baseline TLG  = 0.03) optimal cutoff 75.15. Additionally, ΔTLG also associated  = 0.01 0.03, respectively). Conclusion PET is but are prognostic