Sodium and calcium movements in dog red blood cells.
作者： J C Parker
DOI: 10.1085/JGP.71.1.1
关键词: Calcium 、 Biochemistry 、 Extracellular 、 Intracellular 、 Sodium 、 Quinidine 、 Ion transporter 、 Efflux 、 Biophysics 、 Chemistry 、 Saturation vapor curve
摘要: Determinants of 45Ca influx, efflux, and 22Na efflux were examined in dog red blood cells. influx is strongly influenced by the Na concentration on either side membrane, being stimulated intracellular inhibited extracellular Na. A saturation curve obtained when Ca plotted as a function medium concentration. The maximum pH (increasing with greater alkalinity) cell volume swelling). Quinidine inhibits influx. Efflux increasing concentrations or medium, effects two ions are mutually exclusive rather than additive. Ca-activated efflux. results considered terms model for Ca-Na exchange, it concluded that system shows many features such coupled ion transport system. However, stoichiometric ratio between Ca-dependent highly variable under different experimental conditions. Because fluxes may reflect combination ATP-dependent, outward Na-linked passive movements, true stoichiometry an exchanger not be ascertainable absence specific pump inhibitor. meaning these observations regulation cells discussed.
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