Embryological and molecular development of the adrenal glands.

作者: Ian L. Ross , Graham J. Louw

DOI: 10.1002/CA.22422

关键词: PrimordiumGonadKidneyAdrenal cortexEndocrinologyAdrenal glandTranscription factorInternal medicineBiologyAdrenocorticotrophic hormoneCongenital adrenal hypoplasiaPathology

摘要: In this mini review, the embryological and functional development of adrenal glands is presented from a molecular perspective. While acknowledging that highly complex series events, processes are described in simple broad strokes single text for reader who interested field but not an active researcher. The origin mesodermal ridge as early fourth week gestation. Between eighth ninth weeks gestation, encapsulated results presence distinct organ. There have been great strides deciphering very complicated aspects gland which multiple transcription factors identified, directing adrenogonadal primordium into cortex, kidney, or bipotential gonad. Adrenocorticotrophic hormone critical hypothalamic-pituitary axis. Several mutations factors, responsible normal found to induce familial syndrome congenital hypoplasia neoplasia.

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