Pontine hyperperfusion in sporadic hyperekplexia
作者： R. Vetrugno , M. Mascalchi , A. Vella , R. D. Nave , L. Guerrini
关键词: Brainstem 、 Startle reaction 、 Neuroscience 、 Psychology 、 Hyperekplexia 、 Cingulate cortex 、 Cerebral blood flow 、 Pons 、 Superior frontal gyrus 、 Neuroimaging
摘要: Objective: To explore with neuroimaging techniques the anatomical and functional correlates of sporadic hyperekplexia. Methods: Two elderly women hyperekplexia underwent neurophysiological assessment, MRI brain proton magnetic resonance spectroscopy ( 1 H-MRS) brainstem frontal lobes. Regional cerebral blood flow was investigated single photon emission tomography (SPECT) during evoked startles at rest. Results: Both patients showed excessively large non-habituating startle responses. In both patients, impingement by vertebrobasilar artery, lack or abnormalities on H-MRS hyperperfusion in dorsal pons cingulate cortex, superior gyrus SPECT startles. Conclusions: our hyperekplexia, arteries were found to impinge brainstem. Neurophysiological findings neurofunctional imaging indicated a pontine origin movement disorder modulated activation cortical, especially frontal, areas. The human are similar those observed for circuit animals.
elsevier.com
unifi.it
sci-hub.se 参考文章(17)
Athanasios Gaitatzis, Luke D. Kartsounis, Svetislav Gacinovic, Durval C. Costa, Kirsten Harvey, Robert J. Harvey, Rajith N. de Silva, Frontal lobe dysfunction in sporadic hyperekplexia--case study and literature review. Journal of Neurology. ,vol. 251, pp. 91- 98 ,(2004) , 10.1007/S00415-004-0288-4
Anna Pissiota, Orjan Frans, Asa Michelgard, Lieuwe Appel, Bengt Langstrom, Magne Arve Flaten, Mats Fredrikson, Amygdala and anterior cingulate cortex activation during affective startle modulation: a PET study of fear. European Journal of Neuroscience. ,vol. 18, pp. 1325- 1331 ,(2003) , 10.1046/J.1460-9568.2003.02855.X
Markus Frings, Matthias Maschke, Maren Erichsen, Walter Jentzen, Stefan P. M??ller, Florian P. Kolb, Hans-Christoph Diener, Dagmar Timmann, Involvement of the human cerebellum in fear-conditioned potentiation of the acoustic startle response: a PET study. Neuroreport. ,vol. 13, pp. 1275- 1278 ,(2002) , 10.1097/00001756-200207190-00012
P. BROWN, J. C. ROTHWELL, P. D. THOMPSON, T. C. BRITTON, B. L. DAY, C. D. MARSDEN, The hyperekplexias and their relationship to the normal startle reflex. Brain. ,vol. 114, pp. 1903- 1928 ,(1991) , 10.1093/BRAIN/114.4.1903
A. Gambardella, P. Valentino, G. Annesi, R. L. Oliveri, F. Bono, R. L. Mazzei, F. L. Conforti, U. Aguglia, M. Zappia, K. Pardatscher, A. Quattrone, Hyperekplexia in a patient with a brainstem vascular anomaly. Acta Neurologica Scandinavica. ,vol. 99, pp. 255- 259 ,(1999) , 10.1111/J.1600-0404.1999.TB07358.X
John S. Yeomans, Paul W. Frankland, The acoustic startle reflex: neurons and connections. Brain Research Reviews. ,vol. 21, pp. 301- 314 ,(1995) , 10.1016/0165-0173(96)00004-5
Mario Mascalchi, Roberto Brugnoli, Laura Guerrini, Giacomo Belli, Marco Nistri, Letterio S. Politi, Cinzia Gavazzi, Francesco Lolli, Giovanni Argenti, Natale Villari, Single-voxel long TE 1H-MR spectroscopy of the normal brainstem and cerebellum. Journal of Magnetic Resonance Imaging. ,vol. 16, pp. 532- 537 ,(2002) , 10.1002/JMRI.10189
J. P. Sánchez-Navarro, J. M. Martínez-Selva, F. Román, Emotional response in patients with frontal brain damage: effects of affective valence and information content. Behavioral Neuroscience. ,vol. 119, pp. 87- 97 ,(2005) , 10.1037/0735-7044.119.1.87
Chris Rorden, Matthew Brett, Stereotaxic Display of Brain Lesions Behavioural Neurology. ,vol. 12, pp. 191- 200 ,(2000) , 10.1155/2000/421719
Anna Pissiota, Örjan Frans, Mats Fredrikson, Bengt Långström, Magne Arve Flaten, The human startle reflex and pons activation: a regional cerebral blood flow study. European Journal of Neuroscience. ,vol. 15, pp. 395- 398 ,(2002) , 10.1046/J.0953-816X.2001.01870.X