Drosophila melanogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components

作者: Komal Panchal , Anand K. Tiwari

DOI: 10.1016/J.BIOPHA.2017.03.001

关键词: Drosophila melanogasterBotanyIdentification (biology)Computational biologyDrosophilaActive componentsBiologyMedicinal plantsModel organismLiver damageCell signaling pathways

摘要: Plants/plant-derived components have been used from ancient times to treat/cure several human diseases. Plants and their parts possess chemical that play the vital role in improvement of health life expectancy. Allopathic medicines playing a key treatment Though allopathic provide fast relief, long time consumption cause serious concerns such as hyperallergic reactions, liver damage, etc. So, study medicinal plants which rarely any side effect is very important mankind. contain many benefit properties like antioxidant, anti-aging, neuroprotective, anti-genotoxic, anti-mutagenic bioinsecticidal activity. Thus, identification pharmacological plants/plant-derived are utmost importance be explored. Several model organisms identify different or active therein Drosophila one them. melanogaster "fruit fly" well understood, high-throughput organism being more than 110 years biological aspects related development Most developmental cell signaling pathways ∼75% disease-related genes conserved between Drosophila. Using Drosophila, can easily analyze by performing assays available with flies survivorship, locomotor, death, The current review focuses on potential for medicinal/pharmacological associated components.

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