Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem.

摘要: Sweet perception promotes food intake, whereas that of bitterness is inhibitory. Surprisingly, the expression sweet G protein-coupled taste receptor (GPCTR) subunits (T1R2 and T1R3) bitter GPCTRs (T2R116, T2R118, T2R138 T2R104), as well α-subunits associated signalling complex (αGustducin, Gα14 αTransducin), in oral extra-oral tissues from lean obese mice, remains poorly characterized. We focused on impact obesity brain areas involved energy homeostasis, namely hypothalamus brainstem. demonstrate many are co-expressed these decreases T1R3, T2R116, Gα14, αTrans TRPM5. In vitro high levels glucose caused a prominent down-regulation T1R2 cultured hypothalamic neuronal cells, leptin transient T1R3 expression. Intriguingly, differences were also observed other most strikingly duodenum where reduced receptors. conclusion, influences components sensing regions mouse including