Joint Effect of Estrogen Receptor β Sequence Variants and Endogenous Estrogen Exposure on Breast Cancer Risk in Chinese Women

摘要: Long-term estrogen exposure and family history of breast cancer are the two factors that most consistently found to be associated with risk. Sequence variants in genes involved synthesis, metabolism, signal transduction may account, part, for this observation. Using data DNA samples from Shanghai Breast Cancer Study, we tested hypothesis sequence receptor beta gene (ESR2) increased risk cancer, particularly among women who have a high level long-term endogenous exposure. Direct sequencing ESR2 30 Chinese revealed eight variants. Association analysis six common 1134 cases 1235 controls provided evidence positive associations between single nucleotide polymorphisms (SNPs), [C(14206)T C(33390)G], postmenopausal women. Evidence stronger association was SNP [C(33390)G] long duration (> or =34 years) menstruation (odds ratio, 2.37; 95% confidence interval, 1.18-4.77). A potential synergistic effect several steroid sex hormones observed, 3-4-fold elevated CG GG genotype combined hormone low binding globulin. Our results consistent joint on