Estrogen Receptor Gene Polymorphisms and Lung Adenocarcinoma Risk in Never-Smoking Women
作者： Kuan-Yu Chen , Chin-Fu Hsiao , Gee-Chen Chang , Ying-Huang Tsai , Wu-Chou Su
DOI: 10.1097/JTO.0000000000000646
关键词:
摘要: Introduction: The association between estrogen receptor (ER) gene polymorphism and lung cancer risk is rarely studied. This study aimed to explore the ER polymorphisms associated with adenocarcinoma in never-smoking women. Methods: evaluated 532 female patients healthy controls. ESR1 ESR2 single nucleotide (SNP) data were retrieved from a genome-wide study. Using multivariate-adjusted logistic regression assay, associations of SNPs estimated. Expression quantitative trait loci analysis was performed investigate possible functional roles SNPs. Results: For ESR1, seven tagged identified. Among them, rs7753153 rs985192 (rs7753153: odds ratios [OR], 1.509; 95% confidence intervals [CI], 1.168–1.950; rs985192: OR, 1.309; CI, 1.001–1.712). ESR2, only rs3020450 (OR, 2.110; 1.007–4.422). Subjects without hormone replacement therapy (HRT) use carrying at-risk genotypes had significantly higher than subjects HRT no (rs7753153 GG: 2.133; 1.415–3.216; AA/AC, OR: 1.752, CI: 1.109–2.768; AG/GG, 7.162, 1.608–31.90). Risk ( p = 0.0248) rs9479122 0.0251) decreased expression. Conclusions: are joint effects on highlight importance gene–environment interaction carcinogenesis.
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