Stability of (-)-epigallocatechin gallate and its activity in liquid formulations and delivery systems

摘要: (-)-Epigallocatechin gallate (EGCG) has become a popular disease-preventive supplement worldwide because it may aid in slowing down the onset of age-related diseases such as cancer, diabetes and tissue degeneration. As largely demonstrated cell culture studies, EGCG possesses antioxidant properties exhibits favorable effects on gene expression, signal transduction other functions. However, only limited have been observed experimental animals human epidemiological studies. The inconsistency between biological activity cultures vivo can be attributed to its low stability, which not decreases bioavailability but also leads formation degradation products prooxidant molecules with possible side-effects. Understanding kinetics solution is crucial for successful clinical application. Ambient conditions (pH, temperature, oxygen) either enhance or decrease stability EGCG, thus influencing activity. Usage stabilizers and/or encapsulation into particulate systems nanoparticles microparticles significantly increase stability. In this review, ambient conditions, rate are illustrated.