Therapy of Sporadic and NF2-Related Vestibular Schwannoma.

摘要: Vestibular schwannoma (VS) is a benign primary brain tumor that occurs sporadic or as part of genetic syndrome. The most common cause the mutation NF2 suppressor gene involved in production protein merlin. Merlin plays role cell growth and adhesion. In patients with NF2, VSs arise bilaterally coincide other tumors. VS, typically unilateral does not combination MRI standard imaging technique can be used to assess size aspect well progression disease. preferred management large VS both types surgery without adjuvant radiation. for medium- small-sized includes wait scan, radiotherapy and/or surgery. This choice depends on preference patient institutional protocols. outcomes surgical treatments are improving due progress equipment/approaches, advances radiation delivery techniques dose optimizations main purpose preserving function long possible control.