Polyphosphazene-based nanocarriers for the release of agrochemicals and potential anticancer drugs.

摘要: The synthesis and characterisation of novel polyphosphazene nanocarriers, based on hydrophilic polyalkylene oxide Jeffamine M1000 hydrophobic steroids with a glycinate linker for pH-controlled release diosgenin two brassinosteroids (DI31 S7) agrochemical potential anticancer activity, is hereby described. Polyphosphazenes carrying approximately 17 wt% DI31 or S7 self-assembled in water to form 120–150 nm nanoaggregates, which showed an excellent plant growth effect radish cotyledons due sustained delivery 30% the agrochemicals after 4 days. Cytotoxic evaluation that all polymers resulted strong moderate toxicity MCF-7 cancer cells were non-toxic primary human lung fibroblast at 0.1 0.025 mg mL−1. Thus, bearing applied 10−4 10−6 mL−1 recommended quantities crops should be harmless humans. Particularly, cytotoxicity non-toxicity fibroblasts, good cell uptake 6 hours, proper hydrodynamic sizes between 100 200 nm, slow cytotoxic drugs (DI31, acidic conditions might potentiate their accumulation tissues antitumour effects minor side effects. These results demonstrated preparation brassinosteroid promising strategy better reduced pollutant impact sustainable agriculture formulations analogues brassinosteroids.