Water-Soluble, Biocompatible Polyphosphazenes with Controllable and pH-Promoted Degradation Behavior.
作者： Sandra Wilfert , Aitziber Iturmendi , Wolfgang Schoefberger , Kushtrim Kryeziu , Petra Heffeter
DOI: 10.1002/POLA.27002
关键词:
摘要: The synthesis of a series novel, water-soluble poly(organophosphazenes) prepared via living cationic polymerization is presented. degradation profiles the polyphosphazenes are analyzed by GPC, 31P NMR spectroscopy, and UV–Vis spectroscopy in aqueous media show tunable rates ranging from days to months, adjusted subtle changes chemical structure polyphosphazene. Furthermore, it observed that these polymers demonstrate pH-promoted hydrolytic behavior, with remarkably faster rate at lower pH values. These degradable, water soluble controlled molecular weights structures could be significant interest for use biomedical applications, such as polymer therapeutics, which biological clearance requirement this context cell viability tests described non-toxic nature well their intermediates products. © 2013 Authors Journal Polymer Science Part A: Chemistry Published Wiley Periodicals, Inc. J. Polym. Sci., Chem. 2014, 52, 287–294
harvard.edu
sci-hub.se 参考文章(46)
K Ulbrich, T Etrych, P Chytil, M Jelı́nková, B Řı́hová, HPMA copolymers with pH-controlled release of doxorubicin Journal of Controlled Release. ,vol. 87, pp. 33- 47 ,(2003) , 10.1016/S0168-3659(02)00348-6
Jan H.L. Crommen, Etienne H. Schacht, Erik H.G. Mense, Biodegradable polymers. II. Degradation characteristics of hydrolysis-sensitive poly[(organo)phosphazenes]. Biomaterials. ,vol. 13, pp. 601- 611 ,(1992) , 10.1016/0142-9612(92)90028-M
J Paulsdorf, M Burjanadze, K Hagelschur, H-D Wiemhöfer, Ionic conductivity in polyphosphazene polymer electrolytes prepared by the living cationic polymerization Solid State Ionics. ,vol. 169, pp. 25- 33 ,(2004) , 10.1016/J.SSI.2004.01.012
Vivienne Blackstone, Alan J. Lough, Martin Murray, Ian Manners, Probing the mechanism of the PCl5-initiated living cationic polymerization of the phosphoranimine Cl3P=NSiMe3 using model compound chemistry. Journal of the American Chemical Society. ,vol. 131, pp. 3658- 3667 ,(2009) , 10.1021/JA808517D
Harry R. Allcock, Nicole L. Morozowich, Bioerodible polyphosphazenes and their medical potential Polymer Chemistry. ,vol. 3, pp. 578- 590 ,(2012) , 10.1039/C1PY00468A
Harry R. Allcock, Shawn R. Pucher, Polyphosphazenes with glucosyl and methylamino, trifluoroethoxy, phenoxy, or (methoxyethoxy)ethoxy side groups Macromolecules. ,vol. 24, pp. 23- 34 ,(1991) , 10.1021/MA00001A005
Bret D. Ulery, Lakshmi S. Nair, Cato T. Laurencin, Biomedical applications of biodegradable polymers Journal of Polymer Science Part B: Polymer Physics. ,vol. 49, pp. 832- 864 ,(2011) , 10.1002/POLB.22259
Shiyi Zhang, Hai Wang, Yuefei Shen, Fuwu Zhang, Kellie Seetho, Jiong Zou, John-Stephen A. Taylor, Andrew P. Dove, Karen L. Wooley, A Simple and Efficient Synthesis of an Acid-labile Polyphosphoramidate by Organobase-catalyzed Ring-Opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment Macromolecules. ,vol. 46, pp. 5141- 5149 ,(2013) , 10.1021/MA400675M
Tomáš Etrych, Markéta Jelı́nková, Blanka Řı́hová, Karel Ulbrich, New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties Journal of Controlled Release. ,vol. 73, pp. 89- 102 ,(2001) , 10.1016/S0168-3659(01)00281-4
Bin Wang, Eric Rivard, Ian Manners, A new high-yield synthesis of Cl(3)P=NSiMe(3), a monomeric precursor for the controlled preparation of high molecular weight polyphosphazenes. Inorganic Chemistry. ,vol. 41, pp. 1690- 1691 ,(2002) , 10.1021/IC011125N